Interactive Report · PGx Interpretation Pipeline

GeT-RM Validation Scorecard

All five gene modules validated against 38 real CDC/GeT-RM reference-material samples — physical DNA samples with independently verified consensus genotypes (Coriell Institute), not synthetic test fixtures. Bars show what actually happened per sample, not just a pass/fail rate: this pipeline is designed to report ambiguity and known scope limits explicitly rather than resolve them by guessing, so "correct" includes samples where the honest answer was "ambiguous" or "out of scope." Hover a segment for the specific Coriell sample IDs.

38 / 38samples produced the documented, correct behavior

30exact diplotype/phenotype matches

4correctly reported as ambiguous (true answer was the primary candidate)

4real samples confirming a documented scope limit

Sources: Pratt VM et al. 2022 (PMID 35850928, TPMT/NUDT15) · Gaedigk A et al. 2024 (PMID 39032822, DPYD) · Pratt VM et al. 2010 (PMID 20889555, CYP2C19) · Pratt VM et al. 2016 (PMID 26621101, SLCO1B1) — all via CDC's public-domain GeT-RM consensus tables / Coriell's GeT-RM PGx Search tool.

Full sample-by-sample detail, including the exact genotype comparisons and the reasoning behind every "ambiguous" and "documented limitation" call, is in docs/VALIDATION.md in the project repository.